Activity Recall in a Visual Cortical Ensemble

Associational memory, as its name implies, is a type of memory that allows one to fuse multiple events in memory. If your boss constantly yells at you in his office, you might begin to form some bad memories of being in that office. While the phenomenon of associative memory is a familiar experience, the neural basis for it isn’t well understood. A prominent theory, which was formed in the mid-20th century but only tested recently is that neurons encode associations by wiring together. In the boss’s office example, the sight of the boss’s office might activate one subset of neurons, and those neurons would then “fill in” activation of neurons that code for fear or memories of yelling (obviously this is a gross oversimplification - I’m only using it to demonstrate the principle).